Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.123 0.211
biological_process el 1648 0.008 1.0 0.617 0.273
biological_process ka 1648 0.0 1.0 0.118 0.21
biological_process rf 1648 0.0 1.0 0.123 0.211
cellular_component ct 1649 0.0 0.981 0.225 0.265
cellular_component el 1649 0.0 1.0 0.445 0.29
cellular_component ka 1649 0.0 0.981 0.221 0.259
cellular_component rf 1649 0.0 0.981 0.225 0.265
disease ct 1462 0.0 1.0 0.044 0.143
disease el 1462 0.0 0.998 0.432 0.297
disease ka 1462 0.0 0.993 0.038 0.128
disease rf 1462 0.0 0.998 0.044 0.143
genetic_interaction ct 1606 0.0 1.0 0.417 0.327
genetic_interaction el 1606 0.0 0.987 0.425 0.322
genetic_interaction ka 1606 0.0 0.152 0.028 0.036
genetic_interaction rf 1606 0.0 0.987 0.419 0.329
molecular_function ct 1634 0.0 0.995 0.266 0.295
molecular_function el 1634 0.0 1.0 0.449 0.268
molecular_function ka 1634 0.0 0.98 0.257 0.286
molecular_function rf 1634 0.0 0.995 0.265 0.295
pathway ct 653 0.0 1.0 0.29 0.333
pathway el 653 0.0 0.774 0.214 0.295
pathway ka 653 0.0 0.242 0.021 0.039
pathway rf 653 0.0 0.774 0.207 0.291
phenotype ct 1480 0.0 0.998 0.076 0.168
phenotype el 1480 0.0 0.999 0.527 0.29
phenotype ka 1480 0.0 0.962 0.074 0.172
phenotype rf 1480 0.0 0.997 0.076 0.168
protein_interaction ct 1657 0.0 1.0 0.07 0.163
protein_interaction el 1657 0.0 0.933 0.065 0.157
protein_interaction ka 1657 0.0 0.156 0.007 0.018
protein_interaction rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 0.955 0.235 0.266
integration_mean_by_presence el 1676 0.0 0.976 0.427 0.287
integration_mean_by_presence ka 1676 0.0 0.966 0.069 0.152
integration_mean_by_presence rf 1676 0.0 0.929 0.055 0.12
mean ct 1676 0.0 0.955 0.144 0.239
mean el 1676 0.0 0.978 0.209 0.248
mean ka 1676 0.0 0.966 0.042 0.128
mean rf 1676 0.0 0.971 0.044 0.105

CDF plots of non integrated kernels

CDF plots of integrated kernels